The Eremophila galeata, a plant that is part of the traditional heritage of the Australian aborigines, has interesting properties for the fight against cancer
Don't store avocado like this: it's dangerousResearch continues to find new drugs and active ingredients capable of blocking cancer or enhancing existing therapies. Scientists recently seem to have found a valuable remedy in a plant that lives in the Australian desert.
The latest discovery, made by a research team at the University of Copenhagen, could increase the effectiveness of cancer therapies. Scientists paused to analyze the potential of a typical plant of the Australian desert: the Eremophila galeata, which has been part of traditional Aboriginal medicine for centuries.
The research results, published in the scientific journal Biomolecules, show how this plant can help break cancer drug resistance. The problem that often presents itself for the sick, in fact, is that the cancer cells do not respond to chemotherapy.
However, Danish scientists have discovered that the resin of Eremophila galeata contains a specific flavonoid that can block efflux pumps in cancer cells, that is, to remove the cellular defense mechanism against chemotherapy. Experiments have shown that resistance to the SN-38 cancer drug, irinotecan (particularly used in the treatment of advanced colorectal cancer) can be overcome in this way.
As botanist Dan Stærk of the University of Copenhagen, one of the authors of the new study, explained:
We already have products that inhibit efflux pumps, but they don't work optimally because they aren't specific enough and have too many side effects.
The new research concluded that resin from this species significantly enhances the effect of chemotherapy on HT29 colon cancer cells.
Of course this is only the first step, in fact more in-depth studies are needed before a new drug can be developed that can increase the effectiveness of chemotherapy.
Exploiting the flavonoid mechanism present in Eremophila galeata could also be useful in antibiotic resistance.
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Source: Biomolecules
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