Pisa researchers discover how to regenerate and heal the heart after a heart attack

    An exceptional discovery for those with a "battered" heart. Researchers from the Institute of Life Sciences of the Sant'Anna School of Pisa, together with those of the International Center for Genetic Engineering and Biotechnology (ICGEB) of Trieste, have discovered how to stimulate the regeneration of the heart after a heart attack, by activating proliferation of heart cells.



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    An exceptional discovery for those with a "bad heart". Researchers from the Institute of Life Sciences of the Sant'Anna School of Pisa, together with those of the International Center for Genetic Engineering and Biotechnology (ICGEB) of Trieste, have discovered how to stimulate regeneration of the heart after a heart attack, activating the proliferation of heart cells.



    The secret? A small "miraculous" pill, inspired once again by nature, in particular by the extraordinary mechanism of spontaneous regeneration of the heart of fish and salamanders.

    The study, published in Nature, showed how the administration of a small RNA, called microRNA-199, is able to stimulate the regeneration of the heart, leading to almost complete recovery of heart function one month after the heart attack.

    “It will take some time before we can start the clinical trial using this new therapy” explain Fabio Recchia and Mauro Jacket. “The treatment so far has been carried out using a modified virus to carry the RNA molecules into the heart cells, but this does not allow precise control of the dosage, causing undesirable effects in the long run. We must learn to administer RNA as if it were a synthetic drug; we already know that it is possible ”.

    Pisa researchers discover how to regenerate and heal the heart after a heart attack

    The study was conducted in collaboration with the Monasterio Foundation in Pisa and the School of Cardiovascular Medicine & Sciences of King's College London, where Mauro Jacket is moving his research team to continue his research on the development of new biological drugs for heart disease.



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