High-fat diet: the side effect on your gut just discovered by scientists

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Elia Tabuenca García
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A new American study reveals that a high-fat diet increases the risk of colon and bowel cancer

Don't store avocado like this: it's dangerous

A new American study reveals that a high-fat diet by interfering with stem cell formation can increase the risk of colon and bowel cancer.





For decades, nutritionists have urged us to limit the consumption of high-fat foods, blamed for causing diseases such as diabetes, heart problems and cancer. And in fact, frequent consumption of foods rich in saturated fats (such as red meat) is considered a risk factor in the onset of cancer: changing one's eating habits can reduce the risk of incurring this disease by up to 70%. .

Now, a new study from Arizona State University has highlighted in even greater detail how a high-fat diet can trigger a cascade of events that ultimately lead to colon and bowel cancer. When food is broken up during chewing and begins its path in the digestive system, it comes into contact with the stem cells present in the intestine: it is believed that these cells are the gateway for the formation of intestinal tumors, if they adapt to the massive presence of fatty foods. Inside, in fact, there are molecules that perceive and react to the excessively high levels of fats contained in foods.

We were following the mechanisms that stem cells adopt to adapt to a diet rich in large intestines and we came across peroxisomal proliferator-activated receptors (PPARs) - explains Miyeko Mana, author of the study. - These deceive the programming of the cell which raises the risk of cancer, even if the mechanism was unclear: there are in fact different types of these receptors in the human body.

(Read: Too much sugar damages the brain and memory)

From these data, the team was able to trace the development of cancer, from nutrition to tumor formation. First, fats are broken down into free fatty acids which stimulate sensors in the gut (such as PPARs) and activate genes that can destroy them. Then, the excess fatty acids are carried into the mitochondria, which burn them to create more energy and thus nourish the stem cells - which multiply, grow and regenerate intestinal tissue. But when stem cells are in excess, there is a greater chance of mutation, which can lead to colon cancer. In practice, this excessive amount of cells remains in the intestine, accumulating mutations that can give life to the tumor mass.



@cell.com

Fonte: Cell Reports

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