A new study, conducted by scientists from Beijing's Tsinghua University, has discovered the engine that allows Covid-19 to multiplyDon't store avocado like this: it's dangerous
Il coronavirus it may have fewer and fewer secrets. A new study, conducted by scientists from Beijing's Tsinghua University, has discovered the engine that allows Covid-19 to multiply.
The secret is in fact contained in an enzyme, called nsp12 polymerase. The research team led by Yan Gao has closely observed this molecular motor that causes SarsCoV2 to multiply.
The nsp12 polymerase enzyme, among other things, is the target of the remdesivir antiviral originally used against Ebola but recently also exploited against the coronavirus.
"RNA-dependent RNA polymerase (RdRp, also called nsp12) is the central component of the coronaviral replication and transcription mechanism and appears to be a primary target for the antiviral drug, remdesivir," the study reads. “In addition to the conserved architecture of the polymerase nucleus of the viral polymerase family, nsp12 possesses a recently identified β-hairpin domain at its N terminus. A comparative analysis model shows how remdesivir binds to this polymerase. The facility provides a basis for the design of new antiviral therapies targeting viral RdRp ”.
That's right, the discovery could help research into targeted drugs that can fight the coronavirus.
Sources of reference: Science
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