Alzheimer's: 42 genes discovered that help calculate risk of getting sick in largest genetic study on dementia

Alzheimer's: 42 genes discovered that help calculate risk of getting sick in largest genetic study on dementia

The largest genetic study in Alzheimer's disease has identified 42 genes, which may be the key to diagnosing early risk of getting sick. According to the data, the disease is connected to a disruption of the brain's immune system.


Don't store avocado like this: it's dangerous

The largest genetic study in Alzheimer's has provided compelling evidence, linking the disease to stopping immune system of the brain.




The study, using the genomes of 100.000 people with Alzheimer's and 600.000 healthy people, identified 75 genes linked to an increased risk of the disease, including 42 that had not previously been implicated.

(Read also: Alzheimer's: Walking at this speed after age 60 can be one of the first signs of dementia)

A systematic review

The research findings suggest that degeneration in the brains of patients with dementia may be stimulated by "overly aggressive" activity in the brain's immune cells, called microglia.

Professor Julie Williams, director of the UK's Dementia Research Institute at Cardiff University and co-author of the study, said:

The findings could help rekindle efforts to find an effective treatment. Eight or nine years ago we weren't working on the immune system. Genetics has redirected us.

The study, the largest of its kind to date, also allowed scientists to come up with a genetic risk score that could predict which patients with cognitive impairment would develop Alzheimer's within three years of first onset of symptoms. .

Previous research has shown that while lifestyle factors, such as smoking,physical exercise and diet affect Alzheimer's risk, 60% -80% of the risk is based on genetics.

The risk genes highlighted in the study include those that affect the efficiency of the brain's immune cells, which in people at risk appear to function too aggressively.

Dr Susan Kohlhaas, Director of Research at Alzheimer's Research UK, said:

Creating a complete list of genes at risk for Alzheimer's disease is like putting the pieces of a puzzle together, and while this work doesn't give us the full picture, it does provide a valuable framework for future developments. The research, however, also tells us how complex Alzheimer's is, with different mechanisms involved in the development of the disease.



Follow us on Telegram | Instagram | Facebook | TikTok |   Youtube

Photos: Nature

Sull 'Alzheimer could it be interesting for you:

  • Alzheimer's: Discover how many hours a night you should sleep if you're over 70 to prevent cognitive decline (and I'm not 8)
  • Alzheimer's: What if it was all about energy production?
  • Dementia: This diet can reduce the risk of Alzheimer's by more than 50% according to one study
  • Alzheimer's: study links disease to sleep loss and circadian rhythm for the first time
  • Discovered what different people with Alzheimer's gene mutation have in their brains
  • Alzheimer's: dementia can be diagnosed with a blood test, the revolutionary discovery
add a comment of Alzheimer's: 42 genes discovered that help calculate risk of getting sick in largest genetic study on dementia
Comment sent successfully! We will review it in the next few hours.